His first starring role was as Tony Villicana on the television series The Greatest American Hero. His best-known film roles were as Eddie Wilson in Eddie and the Cruisers (1983) and its sequel Eddie and the Cruisers II: Eddie Lives! (1989), as well as Streets of Fire (1984) and The Philadelphia Experiment (1984). (Paré also appeared in the 2012 remake of The Philadelphia Experiment.) Other films included Moon 44 (1990), Village of the Damned (1995), Bad Moon (1996), Hope Floats (1998), and The Virgin Suicides (1999).

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